Reactome | Dephosphorylation of STAT1 by SHP2

Schema > Reaction > Entries

Dephosphorylation of STAT1 by SHP2 Show undefined attributes

catalystActivity	[CatalystActivity:10374396] protein tyrosine phosphatase activity of PTPN11 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10374398
displayName	Dephosphorylation of STAT1 by SHP2
eventOf	[Pathway:R-BTA-912694] Regulation of IFNA/IFNB signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-997309] Dephosphorylation of STAT1 by SHP2 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-BTA-909711] IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Dephosphorylation of STAT1 by SHP2
output	[Complex:R-BTA-997304] IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-997309
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-912694] Regulation of IFNA/IFNB signaling
(inferredTo)	[Reaction:R-HSA-997309] Dephosphorylation of STAT1 by SHP2

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