Reactome | Interleukin-27 dissociates from Interleukin-27 receptor

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Interleukin-27 dissociates from Interleukin-27 receptor Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10426820
displayName	Interleukin-27 dissociates from Interleukin-27 receptor
eventOf	[Pathway:R-BTA-9020956] Interleukin-27 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8950210] Interleukin-27 dissociates from Interleukin-27 receptor - Homo sapiens
input	[Complex:R-BTA-448431] IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Interleukin-27 dissociates from Interleukin-27 receptor
output	[Complex:R-BTA-448442] IL27:EBI3 [extracellular region] [Complex:R-BTA-8950163] IL27RA:JAK1 [plasma membrane] [Complex:R-BTA-1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
regulatedBy	[NegativeRegulation:10426821] Negative regulation by 'IL27 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8950210
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9020956] Interleukin-27 signaling
(inferredTo)	[Reaction:R-HSA-8950210] Interleukin-27 dissociates from Interleukin-27 receptor

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