Reactome | p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K

Schema > BlackBoxEvent > Entries

p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10421200
displayName	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
eventOf	[Pathway:R-BTA-8853659] RET signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K - Homo sapiens
input	[Complex:R-BTA-8855302] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] [DefinedSet:R-BTA-508248] p85-containing Class 1A PI3Ks [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
output	[Complex:R-BTA-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane]
precedingEvent	[BlackBoxEvent:R-BTA-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-8854905
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8853659] RET signaling
(inferredTo)	[BlackBoxEvent:R-HSA-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K

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