Reactome | beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)

Schema > Reaction > Entries

beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA) Show undefined attributes

catalystActivity	[CatalystActivity:10334634] methylcrotonoyl-CoA carboxylase activity of 6x(Btn-MCCC1:MCCC2) [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10334636
displayName	beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)
eventOf	[Pathway:R-BTA-70895] Branched-chain amino acid catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-70785] beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA - Bos taurus
inferredFrom	[Reaction:R-HSA-70773] beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA) - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-70744] bMC-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29896] HCO3- [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA) 3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate => 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-70772] bMG-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-70745] isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-70773
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-BTA-70785] beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA
(inferredTo)	[Reaction:R-HSA-70773] beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)

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