Reactome | Glyoxylate metabolism and glycine degradation

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Glyoxylate metabolism and glycine degradation Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444442
displayName	Glyoxylate metabolism and glycine degradation
eventOf	[Pathway:R-BTA-71291] Metabolism of amino acids and derivatives - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:537] carboxylic acid metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-6784224] PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate - Bos taurus [Reaction:R-BTA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Bos taurus [Reaction:R-BTA-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Bos taurus [Reaction:R-BTA-6784423] HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate - Bos taurus [Reaction:R-BTA-904864] Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate - Bos taurus [Reaction:R-BTA-389821] glycine + O2 => glyoxylate + H2O2 + NH4+ - Bos taurus [Reaction:R-BTA-6810076] DDO oxidizes D-Asp to OA - Bos taurus [Reaction:R-BTA-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Bos taurus [Reaction:R-BTA-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Bos taurus [Reaction:R-BTA-389842] HAO1 tetramer oxidizes glycolate to glyoxylate - Bos taurus [Reaction:R-BTA-389862] Conversion of glyoxylate to oxalate - Bos taurus [Pathway:R-BTA-6783984] Glycine degradation - Bos taurus [Reaction:R-BTA-6798317] GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC - Bos taurus
inferredFrom	[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Glyoxylate metabolism and glycine degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-389661
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-BTA-70268] Pyruvate metabolism [Pathway:R-BTA-9857492] Protein lipoylation
(inferredTo)	[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation
(hasEvent)	[Pathway:R-BTA-71291] Metabolism of amino acids and derivatives

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