Reactome | HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)

Schema > Reaction > Entries

HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1) Show undefined attributes

catalystActivity	[CatalystActivity:10418293] estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B14 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10418295
displayName	HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)
eventOf	[Pathway:R-BTA-193144] Estrogen biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6810594] HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1) - Homo sapiens
input	[SimpleEntity:R-ALL-193132] EST17b [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)
output	[SimpleEntity:R-ALL-193066] E1 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-BTA-193143] CYP19A1 hydroxylates TEST to EST17b - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-6810594
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-193144] Estrogen biosynthesis
(inferredTo)	[Reaction:R-HSA-6810594] HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)

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