Reactome | SYK [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-BTA-912625] FYN-like kinases [cytosol] - Bos taurus
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-508449] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] - Bos taurus [Complex:R-BTA-9706276] active FLT3:SYK [plasma membrane] - Bos taurus
consumedByEvent	[Reaction:R-BTA-5621366] SYK binds to p-Y65,Y76-FCER1G - Bos taurus [Reaction:R-BTA-9706336] Active FLT3 binds to SYK - Bos taurus [Reaction:R-BTA-5684801] p-Y7-CLEC1B dimer:PDPN binds SYK - Bos taurus [Reaction:R-BTA-429415] SYK binds to integrin alphaIIb beta3 - Bos taurus [Reaction:R-BTA-429415] SYK binds to integrin alphaIIb beta3 - Bos taurus [Reaction:R-BTA-508292] SYK binds IL2RB - Bos taurus [Reaction:R-BTA-2454240] Recruitment of SYK to p-FCERI gamma subunit - Bos taurus [Reaction:R-BTA-983700] SYK binds the activated BCR - Bos taurus [Reaction:R-BTA-139842] Binding of Syk tyrosine kinase - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10341664
displayName	SYK [cytosol]
endCoordinate	635
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-58268] SYK [cytosol] - Homo sapiens
maxDepth	1
name	SYK SYK A0A3Q1MHG9
referenceEntity	[ReferenceGeneProduct:uniprot:A0A3Q1MHG9] UniProt:A0A3Q1MHG9
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-58268
startCoordinate	1

(input)	[Reaction:R-BTA-9706336] Active FLT3 binds to SYK [Reaction:R-BTA-5684801] p-Y7-CLEC1B dimer:PDPN binds SYK [Reaction:R-BTA-429415] SYK binds to integrin alphaIIb beta3 [Reaction:R-BTA-508292] SYK binds IL2RB [Reaction:R-BTA-5621366] SYK binds to p-Y65,Y76-FCER1G [Reaction:R-BTA-2454240] Recruitment of SYK to p-FCERI gamma subunit [Reaction:R-BTA-983700] SYK binds the activated BCR [Reaction:R-BTA-139842] Binding of Syk tyrosine kinase
(hasComponent)	[Complex:R-BTA-9706276] active FLT3:SYK [plasma membrane] [Complex:R-BTA-429424] Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] [Complex:R-BTA-508449] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] [Complex:R-BTA-5621149] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] [Complex:R-BTA-2454243] Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] [Complex:R-BTA-983693] Antigen:p-BCR:SYK [plasma membrane] [Complex:R-BTA-434911] GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] [Complex:R-BTA-5684799] p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane]
(hasCandidate)	[CandidateSet:R-BTA-912625] FYN-like kinases [cytosol]
(activeUnit)	[CatalystActivity:10367072] non-membrane spanning protein tyrosine kinase activity of GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-58268] SYK [cytosol]

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