Reactome | DNA-PKcs autophosphorylates

Schema > Reaction > Entries

DNA-PKcs autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10408522] protein serine/threonine kinase activity of PRKDC:XRCC5:XRCC6:DNA DSB ends [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10408524
displayName	DNA-PKcs autophosphorylates
eventOf	[Pathway:R-BTA-5693571] Nonhomologous End-Joining (NHEJ) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Bos taurus
inferredFrom	[Reaction:R-HSA-5693575] DNA-PKcs autophosphorylates - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-BTA-75907] PRKDC:XRCC5:XRCC6:DNA DSB ends [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DNA-PKcs autophosphorylates
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-BTA-5687154] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB ends [nucleoplasm]
precedingEvent	[Reaction:R-BTA-5693615] Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5693575
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5693571] Nonhomologous End-Joining (NHEJ)
(precedingEvent)	[Reaction:R-BTA-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs
(inferredTo)	[Reaction:R-HSA-5693575] DNA-PKcs autophosphorylates