Reactome | Activated ATM phosphorylates ABL1

Schema > Reaction > Entries

Activated ATM phosphorylates ABL1 Show undefined attributes

catalystActivity	[CatalystActivity:10355643] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10406309
displayName	Activated ATM phosphorylates ABL1
eventOf	[Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-8956659] ABL1 phosphorylates YAP1 - Bos taurus [Reaction:R-BTA-5686587] ABL1 phosphorylates RAD52 - Bos taurus
inferredFrom	[Reaction:R-HSA-5686578] Activated ATM phosphorylates ABL1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-5686579] ABL1 [nucleoplasm] [SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated ATM phosphorylates ABL1
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5686576] phospho-p-S456-ABL1 [nucleoplasm]
precedingEvent	[Reaction:R-BTA-5693540] MRN activates ATM - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5686578
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-8956659] ABL1 phosphorylates YAP1 [Reaction:R-BTA-5686587] ABL1 phosphorylates RAD52
(hasEvent)	[Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(inferredTo)	[Reaction:R-HSA-5686578] Activated ATM phosphorylates ABL1