Reactome | TNFR1-induced NF-kappa-B signaling pathway

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TNFR1-induced NF-kappa-B signaling pathway Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445454
displayName	TNFR1-induced NF-kappa-B signaling pathway
eventOf	[Pathway:R-BTA-75893] TNF signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20248] canonical NF-kappaB signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) - Bos taurus [BlackBoxEvent:R-BTA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Bos taurus [Reaction:R-BTA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Bos taurus [Reaction:R-BTA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex - Bos taurus [Reaction:R-BTA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Bos taurus
inferredFrom	[Pathway:R-HSA-5357956] TNFR1-induced NF-kappa-B signaling pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TNFR1-induced NF-kappa-B signaling pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-5357956
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-75893] TNF signaling
(inferredTo)	[Pathway:R-HSA-5357956] TNFR1-induced NF-kappa-B signaling pathway

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