Reactome | phospho-p-T342,T345,S346-IRAK4 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10365704
displayName	phospho-p-T342,T345,S346-IRAK4 [cytosol]
endCoordinate	460
hasModifiedResidue	[ModifiedResidue:10365700] O-phospho-L-threonine at 342 (in Homo sapiens) [ModifiedResidue:10365701] O-phospho-L-threonine at 345 (in Homo sapiens) [ModifiedResidue:10365702] O-phospho-L-serine at 346 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-446649] p-T342,T345,S346-IRAK4 [cytosol] - Homo sapiens
maxDepth	1
name	phospho-p-T342,T345,S346-IRAK4 Q1RMT8
producedByEvent	[Reaction:R-BTA-446894] TRAF6 binding leads to IRAK1:TRAF6 release - Bos taurus
referenceEntity	[ReferenceGeneProduct:uniprot:Q1RMT8] UniProt:Q1RMT8
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-446649
startCoordinate	1

(activeUnit)	[CatalystActivity:10365732] protein serine/threonine kinase activity of IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-446649] p-T342,T345,S346-IRAK4 [cytosol]
(output)	[Reaction:R-BTA-446894] TRAF6 binding leads to IRAK1:TRAF6 release
(hasComponent)	[Complex:R-BTA-446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]

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