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phospho-p-T342,T345,S346-IRAK4 [cytosol]
Stable Identifier
R-BTA-446649
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
Q1RMT8
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IRAK1 binds to MYD88 within the IL1R complex (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IRAK4 is activated by autophosphorylation (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IRAK4 phosphorylates IRAK1 (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IRAK4-activated IRAK1 autophosphorylates (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q1RMT8
Reference Genes
BioGPS Gene:533692
ENSEMBL:ENSBTAG00000021105
ENSEMBL:ENSBTAG00000021105.5
KEGG Gene (Bos taurus):533692
Monarch:533692
NCBI Gene:533692
Reference Transcript
RefSeq:NM_001075998.1
RefSeq:XM_005206426.3
Other Identifiers
533692
GO:0000166
GO:0000287
GO:0002376
GO:0002446
GO:0003824
GO:0004672
GO:0004674
GO:0005149
GO:0005524
GO:0005634
GO:0005737
GO:0005886
GO:0006468
GO:0007165
GO:0008063
GO:0009986
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019901
GO:0023052
GO:0035556
GO:0036211
GO:0038172
GO:0043123
GO:0043226
GO:0045087
GO:0048870
GO:0070498
GO:0071222
GO:0098542
GO:0106310
GO:0140096
GO:1990266
Participates
as an output of
TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)
as a component of
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
Other forms of this molecule
IRAK4 [cytosol]
Inferred From
p-T342,T345,S346-IRAK4 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 342 (in Homo sapiens)
Coordinate
342
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 345 (in Homo sapiens)
Coordinate
345
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 346 (in Homo sapiens)
Coordinate
346
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001069466.1
,
XP_005206483.1
IntEnz
2.7.11.1
Ensembl
ENSBTAT00000028115
,
ENSBTAG00000021105
,
ENSBTAP00000028115
VGNC
30268
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