Reactome | GRB2:SOS provides linkage to MAPK signaling for Integrins

Schema > Pathway > Entries

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444302
displayName	GRB2:SOS provides linkage to MAPK signaling for Integrins
eventOf	[Pathway:R-BTA-354192] Integrin signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-354087] Recruitment of GRB2 to p-PTK2 - Bos taurus [Reaction:R-BTA-354165] Interaction of SOS with GRB2 bound to FADK1 - Bos taurus
inferredFrom	[Pathway:R-HSA-354194] GRB2:SOS provides linkage to MAPK signaling for Integrins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	GRB2:SOS provides linkage to MAPK signaling for Integrins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-354194
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-354192] Integrin signaling
(inferredTo)	[Pathway:R-HSA-354194] GRB2:SOS provides linkage to MAPK signaling for Integrins

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