Reactome | Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9

Schema > Reaction > Entries

Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 Show undefined attributes

catalystActivity	[CatalystActivity:10387698] protein serine/threonine kinase activity of CDK8:CCNC/ CDK9:CCNT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10387700
displayName	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
eventOf	[Pathway:R-BTA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-2179274] SMURF2 binds SMAD3 phosphorylated in the linker region - Bos taurus
inferredFrom	[Reaction:R-HSA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [DefinedSet:R-BTA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [DefinedSet:R-BTA-2176487] p-T,2S-SMAD2,3:SMAD4 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-BTA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2176475
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
(precedingEvent)	[Reaction:R-BTA-2179274] SMURF2 binds SMAD3 phosphorylated in the linker region
(inferredTo)	[Reaction:R-HSA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9

Cite Us!