Reactome | MHC class II antigen presentation

Schema > Pathway > Entries

MHC class II antigen presentation Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445200
displayName	MHC class II antigen presentation
eventOf	[Pathway:R-BTA-1280218] Adaptive Immune System - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:14664] antigen processing and presentation of exogenous peptide antigen via MHC class II
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-2213239] Formation of MHC II alpha beta heterodimer - Bos taurus [Reaction:R-BTA-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Bos taurus [Reaction:R-BTA-2213241] Formation of nonameric complex - Bos taurus [Reaction:R-BTA-8951500] Dissociation of CANX from nonameric complex - Bos taurus [Reaction:R-BTA-2130731] Formation of COPII vesicle - Bos taurus [Reaction:R-BTA-2213243] Fusion of COPII vesicle with Golgi complex - Bos taurus [BlackBoxEvent:R-BTA-2130393] Transport of MHC II:Ii complex along Golgi to TGN - Bos taurus [BlackBoxEvent:R-BTA-2130619] TGN-lysosomal vesicle coat assembly - Bos taurus [Reaction:R-BTA-8951498] Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex - Bos taurus [Reaction:R-BTA-2130641] Translocation of TGN-lysosome vesicle to lysosome - Bos taurus [Reaction:R-BTA-2213236] TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome - Bos taurus [BlackBoxEvent:R-BTA-2130378] Transport of MHC II:Ii complex to plasma membrane - Bos taurus [BlackBoxEvent:R-BTA-2130500] Insertion of MHC II:Ii complex in to the plasma membrane - Bos taurus [Reaction:R-BTA-2130640] Recruitment of clathrin coated vesicle by Ii - Bos taurus [BlackBoxEvent:R-BTA-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Bos taurus [Reaction:R-BTA-2130486] Uncoating of clathrin-coated vesicles and fusion with endosomes - Bos taurus [BlackBoxEvent:R-BTA-2213235] Trafficking of nonameric complex in the endocytic pathway - Bos taurus [Reaction:R-BTA-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Bos taurus [Reaction:R-BTA-2130504] Cleavage of lip22 to lip10 - Bos taurus [Reaction:R-BTA-2130349] Generation of CLIP from lip10 - Bos taurus [Reaction:R-BTA-2213246] Disassociation of CLIP from MHC II - Bos taurus [Reaction:R-BTA-2213240] Reduction of disulphide bonds in MHC II antigens - Bos taurus [Reaction:R-BTA-2130706] MHC class II antigen processing - Bos taurus [Reaction:R-BTA-2213244] Loading of antigenic peptides - Bos taurus [BlackBoxEvent:R-BTA-2213248] Transport of antigen loaded MHC II molecules to surface - Bos taurus [Reaction:R-BTA-8856157] LAG3 (CD233) binds MHC II - Bos taurus
inferredFrom	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MHC class II antigen presentation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-2132295
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1280218] Adaptive Immune System
(inferredTo)	[Pathway:R-HSA-2132295] MHC class II antigen presentation

© 2026 Reactome

Cite Us!