Reactome | HLCS biotinylates 6xMCCC1:6xMCCC2

Schema > Reaction > Entries

HLCS biotinylates 6xMCCC1:6xMCCC2 Show undefined attributes

catalystActivity	[CatalystActivity:10390992] biotin--[biotin carboxyl-carrier protein] ligase activity of HLCS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10391039
displayName	HLCS biotinylates 6xMCCC1:6xMCCC2
eventOf	[Pathway:R-BTA-196780] Biotin transport and metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-3323111] Cytosolic carboxylases translocate to mitochondrial matrix - Bos taurus
inferredFrom	[Reaction:R-HSA-2993799] HLCS biotinylates 6xMCCC1:6xMCCC2 - Homo sapiens
input	[Complex:R-BTA-3323185] 6xMCCC1:6xMCCC2 [cytosol] 6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] 6 × [SimpleEntity:R-ALL-199207] Btn [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HLCS biotinylates 6xMCCC1:6xMCCC2
output	[Complex:R-BTA-3323135] 6x(Btn-MCCC1:MCCC2) [cytosol] 6 × [SimpleEntity:R-ALL-76577] AMP [cytosol] 6 × [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-BTA-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2993799
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-196780] Biotin transport and metabolism
(precedingEvent)	[BlackBoxEvent:R-BTA-3323111] Cytosolic carboxylases translocate to mitochondrial matrix
(inferredTo)	[Reaction:R-HSA-2993799] HLCS biotinylates 6xMCCC1:6xMCCC2

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