Reactome | Trans-autophosphorylation of ERBB2 heterodimers

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Trans-autophosphorylation of ERBB2 heterodimers Show undefined attributes

catalystActivity	[CatalystActivity:10382295] protein tyrosine kinase activity of ERBB2 heterodimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10382305
displayName	Trans-autophosphorylation of ERBB2 heterodimers
eventOf	[Pathway:R-BTA-1227986] Signaling by ERBB2 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-6785636] Phosphorylated ERBB2 heterodimers bind MEMO1 - Bos taurus [Reaction:R-BTA-1306953] GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 - Bos taurus [Reaction:R-BTA-1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2 - Bos taurus [Reaction:R-BTA-1358798] RNF41 binds neuregulin-activated ERBB3 - Bos taurus [Reaction:R-BTA-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - Bos taurus [Reaction:R-BTA-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers - Bos taurus [Reaction:R-BTA-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers - Bos taurus [Reaction:R-BTA-8863804] PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 - Bos taurus [Reaction:R-BTA-8847995] Activated ERBB2 binds PTK6 (BRK) - Bos taurus
inferredFrom	[Reaction:R-HSA-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Homo sapiens
input	43 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-BTA-1963573] ERBB2 heterodimers [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Trans-autophosphorylation of ERBB2 heterodimers
output	43 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-BTA-1963585] p-6Y-ERBB2 heterodimers [plasma membrane]
regulatedBy	[NegativeRegulation:10382306] Negative regulation by 'ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]' [NegativeRegulation:10382307] Negative regulation by 'ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1963582
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1227986] Signaling by ERBB2
(precedingEvent)	[Reaction:R-BTA-6785636] Phosphorylated ERBB2 heterodimers bind MEMO1 [Reaction:R-BTA-1306953] GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-BTA-1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2 [Reaction:R-BTA-1358798] RNF41 binds neuregulin-activated ERBB3 [Reaction:R-BTA-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer [Reaction:R-BTA-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers [Reaction:R-BTA-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers [Reaction:R-BTA-8863804] PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [Reaction:R-BTA-8847995] Activated ERBB2 binds PTK6 (BRK)
(inferredTo)	[Reaction:R-HSA-1963582] Trans-autophosphorylation of ERBB2 heterodimers

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