Reactome | MATK (CSK homologous kinase) binds phosphorylated ERBB2

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MATK (CSK homologous kinase) binds phosphorylated ERBB2 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10382267
displayName	MATK (CSK homologous kinase) binds phosphorylated ERBB2
eventOf	[Pathway:R-BTA-8863795] Downregulation of ERBB2 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-1433581] MATK [cytosol] [CandidateSet:R-BTA-1963588] p-ERBB2 heterodimers [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MATK (CSK homologous kinase) binds phosphorylated ERBB2
output	[Complex:R-BTA-1963590] p-ERBB2 heterodimers:MATK [plasma membrane]
precedingEvent	[Reaction:R-BTA-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Bos taurus [Reaction:R-BTA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1963563
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8863795] Downregulation of ERBB2 signaling
(inferredTo)	[Reaction:R-HSA-1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2

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