Reactome | Activated ERBB2 binds PTK6 (BRK)

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Activated ERBB2 binds PTK6 (BRK) Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10419366
displayName	Activated ERBB2 binds PTK6 (BRK)
eventOf	[Pathway:R-BTA-8847993] ERBB2 Activates PTK6 Signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-8848005] ERBB2 promotes PTK6 autophosphorylation - Bos taurus
inferredFrom	[Reaction:R-HSA-8847995] Activated ERBB2 binds PTK6 (BRK) - Homo sapiens
input	[CandidateSet:R-BTA-1963588] p-ERBB2 heterodimers [plasma membrane] [EntityWithAccessionedSequence:R-BTA-8848000] PTK6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated ERBB2 binds PTK6 (BRK)
output	[Complex:R-BTA-8848002] p-ERBB2 heterodimers:PTK6 [plasma membrane]
precedingEvent	[Reaction:R-BTA-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Bos taurus [Reaction:R-BTA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8847995
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8847993] ERBB2 Activates PTK6 Signaling
(precedingEvent)	[Reaction:R-BTA-8848005] ERBB2 promotes PTK6 autophosphorylation
(inferredTo)	[Reaction:R-HSA-8847995] Activated ERBB2 binds PTK6 (BRK)

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