Reactome | Activated FGFR1 binds FRS3

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Activated FGFR1 binds FRS3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10403161
displayName	Activated FGFR1 binds FRS3
eventOf	[Pathway:R-BTA-5654693] FRS-mediated FGFR1 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5654578] Activated FGFR1 phosphorylates FRS3 - Bos taurus
inferredFrom	[Reaction:R-HSA-5654571] Activated FGFR1 binds FRS3 - Homo sapiens
input	[DefinedSet:R-BTA-5654170] Activated FGFR1 [plasma membrane] [EntityWithAccessionedSequence:R-BTA-191482] FRS3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR1 binds FRS3
output	[Complex:R-BTA-5654255] Activated FGFR1:FRS3 [plasma membrane]
precedingEvent	[Reaction:R-BTA-190427] Autocatalytic phosphorylation of FGFR1b - Bos taurus [Reaction:R-BTA-190429] Autocatalytic phosphorylation of FGFR1c - Bos taurus [Reaction:R-BTA-191062] Autocatalytic phosphorylation of Klotho-bound FGFR1c - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5654571
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5654693] FRS-mediated FGFR1 signaling
(precedingEvent)	[Reaction:R-BTA-5654578] Activated FGFR1 phosphorylates FRS3
(inferredTo)	[Reaction:R-HSA-5654571] Activated FGFR1 binds FRS3