Reactome | CDC42:GTP [plasma membrane]

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CDC42:GTP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-BTA-3928566] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] - Bos taurus [Complex:R-BTA-5626465] RAC1,CDC42:GTP:IQGAPs [plasma membrane] - Bos taurus
consumedByEvent	[BlackBoxEvent:R-BTA-9692800] CDC42 translocates to the endoplasmic reticulum membrane - Bos taurus [Reaction:R-BTA-9013161] CDC42 GAPs stimulate CDC42 GTPase activity - Bos taurus [Reaction:R-BTA-389788] Activation of PAKs by RAC1 and CDC42 - Bos taurus [Reaction:R-BTA-5218832] CDC42:GTP binds PAK2 - Bos taurus [Reaction:R-BTA-5218832] CDC42:GTP binds PAK2 - Bos taurus [Reaction:R-BTA-5665727] FMNL2 binds CDC42:GTP - Bos taurus [Reaction:R-BTA-8981931] RAC1 and CDC42 activate PAK2 - Bos taurus [Reaction:R-BTA-8981926] RAC1 and CDC42 activate PAK3 - Bos taurus [Reaction:R-BTA-2029456] RAC1 and CDC42 activate PAK1 - Bos taurus [Reaction:R-BTA-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10347838
displayName	CDC42:GTP [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-BTA-449545] CDC42 [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-449518] CDC42:GTP [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] - Homo sapiens [Complex:R-HSA-182921] CDC42:GTP [plasma membrane] - Homo sapiens
maxDepth	2
name	CDC42:GTP
producedByEvent	[Reaction:R-BTA-9013159] CDC42 GEFs activate CDC42 - Bos taurus [Reaction:R-BTA-2029454] Autophosphorylation of PAK1 - Bos taurus [Reaction:R-BTA-389350] Activation of Cdc42 by pVav1 - Bos taurus [Reaction:R-BTA-8964599] Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex - Bos taurus [Reaction:R-BTA-5627775] Autophosphorylation of PAK1,2,3 - Bos taurus [Reaction:R-BTA-5627775] Autophosphorylation of PAK1,2,3 - Bos taurus [Reaction:R-BTA-5627775] Autophosphorylation of PAK1,2,3 - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-182921
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[BlackBoxEvent:R-BTA-9692800] CDC42 translocates to the endoplasmic reticulum membrane [Reaction:R-BTA-9013161] CDC42 GAPs stimulate CDC42 GTPase activity [Reaction:R-BTA-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs [Reaction:R-BTA-389788] Activation of PAKs by RAC1 and CDC42 [Reaction:R-BTA-5218832] CDC42:GTP binds PAK2 [Reaction:R-BTA-5665727] FMNL2 binds CDC42:GTP [Reaction:R-BTA-8981931] RAC1 and CDC42 activate PAK2 [Reaction:R-BTA-8981926] RAC1 and CDC42 activate PAK3 [Reaction:R-BTA-2029456] RAC1 and CDC42 activate PAK1
(output)	[Reaction:R-BTA-9013159] CDC42 GEFs activate CDC42 [Reaction:R-BTA-8964599] Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex [Reaction:R-BTA-2029454] Autophosphorylation of PAK1 [Reaction:R-BTA-5627775] Autophosphorylation of PAK1,2,3 [Reaction:R-BTA-389350] Activation of Cdc42 by pVav1
(hasComponent)	[Complex:R-BTA-3928566] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] [Complex:R-BTA-448875] Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] [Complex:R-BTA-5672334] RAC1,CDC42:GTP:IQGAP1 [plasma membrane] [Complex:R-BTA-5626465] RAC1,CDC42:GTP:IQGAPs [plasma membrane] [Complex:R-BTA-9014577] G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] [Complex:R-BTA-389782] PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] [Complex:R-BTA-5218772] p-3Y-PAK2 dimer:CDC42:GTP [plasma membrane] [Complex:R-BTA-5218800] p-2Y-PAK2 dimer:CDC42:GTP [plasma membrane] [Complex:R-BTA-5218770] PAK2 dimer:CDC42:GTP [plasma membrane] [Complex:R-BTA-5665735] CDC42:GTP:FMNL2 [plasma membrane] [Complex:R-BTA-182915] Ub-Beta-Pix:CDC42:GTP [cytosol] [Complex:R-BTA-182917] Beta-Pix:CDC42:GTP [cytosol] [Complex:R-BTA-8981927] CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] [Complex:R-BTA-8981928] CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] [Complex:R-BTA-418820] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] [Complex:R-BTA-2029159] RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] [Complex:R-BTA-442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Complex:R-BTA-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-BTA-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane]
(inferredTo)	[Complex:R-HSA-449518] CDC42:GTP [plasma membrane] [DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [Complex:R-HSA-182921] CDC42:GTP [plasma membrane]

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