Reactome | Activation of PAKs by RAC1 and CDC42

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Activation of PAKs by RAC1 and CDC42 Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10360597
displayName	Activation of PAKs by RAC1 and CDC42
eventOf	[Pathway:R-BTA-5687128] MAPK6/MAPK4 signaling - Bos taurus [Pathway:R-BTA-389359] CD28 dependent Vav1 pathway - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-389788] Activation of PAKs by RAC1 and CDC42 - Homo sapiens
input	[Complex:R-BTA-182921] CDC42:GTP [plasma membrane] [DefinedSet:R-BTA-399856] PAK1,2,3 dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of PAKs by RAC1 and CDC42
output	[DefinedSet:R-BTA-390765] PAK1,2,3 [cytosol] [Complex:R-BTA-389782] PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-BTA-389350] Activation of Cdc42 by pVav1 - Bos taurus [Reaction:R-BTA-418850] Activation of Cdc42 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-389788
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5687128] MAPK6/MAPK4 signaling [Pathway:R-BTA-389359] CD28 dependent Vav1 pathway
(inferredTo)	[Reaction:R-HSA-389788] Activation of PAKs by RAC1 and CDC42

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