Reactome | PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

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PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane Show undefined attributes

catalystActivity	[CatalystActivity:10380755] 1-phosphatidylinositol 4-kinase activity of PI4KA/2B [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10380757
displayName	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
eventOf	[Pathway:R-BTA-1483248] Synthesis of PIPs at the ER membrane - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Bos taurus
inferredFrom	[Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1806234] PI4P [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-BTA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Bos taurus [Reaction:R-BTA-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Bos taurus [Reaction:R-BTA-1482626] 2-acyl LPI is acylated to PI by MBOAT7 - Bos taurus [Reaction:R-BTA-1482976] CDP-DAG is converted to PI by CDIPT - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1675813
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1483248] Synthesis of PIPs at the ER membrane
(precedingEvent)	[Reaction:R-BTA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane
(inferredTo)	[Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

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