Reactome | 2-acyl LPI is acylated to PI by MBOAT7

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2-acyl LPI is acylated to PI by MBOAT7 Show undefined attributes

catalystActivity	[CatalystActivity:10378190] 2-acylglycerol-3-phosphate O-acyltransferase activity of MBOAT7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10378192
displayName	2-acyl LPI is acylated to PI by MBOAT7
eventOf	[Pathway:R-BTA-1482922] Acyl chain remodelling of PI - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] - Bos taurus [Reaction:R-BTA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Bos taurus [Reaction:R-BTA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Bos taurus [Reaction:R-BTA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] - Bos taurus [Reaction:R-BTA-1483219] PC is exchanged with PI by PITPNB - Bos taurus
inferredFrom	[Reaction:R-HSA-1482626] 2-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens
input	[SimpleEntity:R-ALL-1498737] 2-acyl LPI [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	2-acyl LPI is acylated to PI by MBOAT7
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-BTA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1482626
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1482922] Acyl chain remodelling of PI
(precedingEvent)	[Reaction:R-BTA-1483219] PC is exchanged with PI by PITPNB [Reaction:R-BTA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] [Reaction:R-BTA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane [Reaction:R-BTA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] [Reaction:R-BTA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13]
(inferredTo)	[Reaction:R-HSA-1482626] 2-acyl LPI is acylated to PI by MBOAT7