Reactome | activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

Schema > Reaction > Entries

activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10342449
displayName	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
eventOf	[Pathway:R-BTA-9769739] Regulation of clotting cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Bos taurus
inferredFrom	[Reaction:R-HSA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Homo sapiens
input	[Complex:R-BTA-156786] activated thrombin (factor IIa) [extracellular region] [EntityWithAccessionedSequence:R-BTA-141030] THBD [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
output	[Complex:R-BTA-141038] activated thrombin:thrombomodulin [plasma membrane]
precedingEvent	[Reaction:R-BTA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-141046
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9769739] Regulation of clotting cascade
(precedingEvent)	[Reaction:R-BTA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
(inferredTo)	[Reaction:R-HSA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

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