Reactome | ATV [cytosol]

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ATV [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Homo sapiens [Reaction:R-MMU-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Mus musculus [Reaction:R-RNO-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Rattus norvegicus [Reaction:R-CFA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Canis familiaris [Reaction:R-BTA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Bos taurus [Reaction:R-SSC-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Sus scrofa [Reaction:R-DRE-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Danio rerio [Reaction:R-XTR-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Xenopus tropicalis [Reaction:R-GGA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Gallus gallus [Reaction:R-HSA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Homo sapiens [Reaction:R-MMU-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Mus musculus [Reaction:R-RNO-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Rattus norvegicus [Reaction:R-CFA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Canis familiaris [Reaction:R-BTA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Bos taurus [Reaction:R-SSC-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Sus scrofa [Reaction:R-DRE-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Danio rerio [Reaction:R-XTR-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Xenopus tropicalis [Reaction:R-GGA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Gallus gallus [BlackBoxEvent:R-HSA-9756156] UGT1A3 lactonizes ATV to ATVL - Homo sapiens [BlackBoxEvent:R-MMU-9756156] UGT1A3 lactonizes ATV to ATVL - Mus musculus [BlackBoxEvent:R-RNO-9756156] UGT1A3 lactonizes ATV to ATVL - Rattus norvegicus
created	[InstanceEdit:9705585] Jassal, Bijay, 2020-10-27
crossReference	[DatabaseIdentifier:9757170] ChEBI:50690 [DatabaseIdentifier:12021187] Mondo:0005439
dbId	9705596
disease	[Disease:9705580] familial hypercholesterolemia [Disease:9611304] cardiovascular system disease
displayName	ATV [cytosol]
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-ALL-9757150] ATVs [cytosol] [DefinedSet:R-ALL-9705575] statins [cytosol]
modified	[InstanceEdit:9757171] Jassal, Bijay, 2021-10-27
name	ATV atorvastatin
producedByEvent	[Reaction:R-BTA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Bos taurus [Reaction:R-HSA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Homo sapiens [Reaction:R-MMU-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Mus musculus [Reaction:R-RNO-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Rattus norvegicus [Reaction:R-CFA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Canis familiaris [Reaction:R-SSC-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Sus scrofa [Reaction:R-DRE-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Danio rerio [Reaction:R-XTR-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Xenopus tropicalis [Reaction:R-GGA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Gallus gallus [Reaction:R-DME-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Drosophila melanogaster [Reaction:R-CEL-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Caenorhabditis elegans [Reaction:R-HSA-9756177] PON1,3 hydrolyse ATVL to ATV - Homo sapiens [Reaction:R-MMU-9756177] PON1,3 hydrolyse ATVL to ATV - Mus musculus [Reaction:R-RNO-9756177] PON1,3 hydrolyse ATVL to ATV - Rattus norvegicus [Reaction:R-CFA-9756177] PON1,3 hydrolyse ATVL to ATV - Canis familiaris [Reaction:R-BTA-9756177] PON1,3 hydrolyse ATVL to ATV - Bos taurus [Reaction:R-SSC-9756177] PON1,3 hydrolyse ATVL to ATV - Sus scrofa [Reaction:R-DRE-9756177] PON1,3 hydrolyse ATVL to ATV - Danio rerio [Reaction:R-XTR-9756177] PON1,3 hydrolyse ATVL to ATV - Xenopus tropicalis [Reaction:R-GGA-9756177] PON1,3 hydrolyse ATVL to ATV - Gallus gallus [Reaction:R-CEL-9756177] PON1,3 hydrolyse ATVL to ATV - Caenorhabditis elegans
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:2949] atorvastatin [Guide to Pharmacology:2949]
schemaClass	ChemicalDrug
stId	R-ALL-9705596

Referrals

(input)	[BlackBoxEvent:R-HSA-9756156] UGT1A3 lactonizes ATV to ATVL [BlackBoxEvent:R-MMU-9756156] UGT1A3 lactonizes ATV to ATVL [BlackBoxEvent:R-RNO-9756156] UGT1A3 lactonizes ATV to ATVL [Reaction:R-HSA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-MMU-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-RNO-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-CFA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-BTA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-SSC-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-DRE-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-XTR-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-GGA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-HSA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-MMU-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-RNO-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-CFA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-BTA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-SSC-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-DRE-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-XTR-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-GGA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV
(output)	[Reaction:R-BTA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-HSA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-MMU-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-RNO-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-CFA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-SSC-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-DRE-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-XTR-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-GGA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-DME-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-CEL-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Reaction:R-HSA-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-MMU-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-RNO-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-CFA-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-BTA-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-SSC-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-DRE-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-XTR-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-GGA-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-CEL-9756177] PON1,3 hydrolyse ATVL to ATV
(hasMember)	[DefinedSet:R-ALL-9757150] ATVs [cytosol] [DefinedSet:R-ALL-9705575] statins [cytosol]

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