Reactome | SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol

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SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10436152] secondary active transmembrane transporter activity of SLCO1B1,1B3,2B1-3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10436154
displayName	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol
eventOf	[Pathway:R-BTA-9754706] Atorvastatin ADME - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region - Bos taurus [Reaction:R-BTA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Bos taurus [Reaction:R-BTA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Bos taurus [Reaction:R-BTA-9705584] HMGCR dimer binds statins - Bos taurus
inferredFrom	[Reaction:R-HSA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Homo sapiens
input	[ChemicalDrug:R-ALL-9756996] ATV [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol Organic anion transporters transport ATV from blood into hepatocytes
output	[ChemicalDrug:R-ALL-9705596] ATV [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9757010
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9754706] Atorvastatin ADME
(precedingEvent)	[Reaction:R-BTA-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region [Reaction:R-BTA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Reaction:R-BTA-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Reaction:R-BTA-9705584] HMGCR dimer binds statins
(inferredTo)	[Reaction:R-HSA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol

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