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2MACA-CoA [mitochondrial matrix]
Stable Identifier
R-ALL-70836
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
alpha-methylacetoacetyl-CoA, 2-methylacetoacetyl-CoA
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Branched-chain amino acid catabolism (Bos taurus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Bos taurus)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Bos taurus)
2MACA-CoA [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Branched-chain amino acid catabolism (Caenorhabditis elegans)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Caenorhabditis elegans)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Caenorhabditis elegans)
2MACA-CoA [mitochondrial matrix]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Branched-chain amino acid catabolism (Canis familiaris)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Canis familiaris)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Canis familiaris)
2MACA-CoA [mitochondrial matrix]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Branched-chain amino acid catabolism (Danio rerio)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Danio rerio)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Danio rerio)
2MACA-CoA [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Branched-chain amino acid catabolism (Dictyostelium discoideum)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Dictyostelium discoideum)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Dictyostelium discoideum)
2MACA-CoA [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Branched-chain amino acid catabolism (Drosophila melanogaster)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Drosophila melanogaster)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Drosophila melanogaster)
2MACA-CoA [mitochondrial matrix]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Branched-chain amino acid catabolism (Gallus gallus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Gallus gallus)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Gallus gallus)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Gallus gallus)
2MACA-CoA [mitochondrial matrix]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of branched-chain amino acid catabolism (Homo sapiens)
Beta-ketothiolase deficiency (Homo sapiens)
ACAT1 mutants don't synthesize propionyl-CoA or acetyl-CoA (Homo sapiens)
2MACA-CoA [mitochondrial matrix]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Homo sapiens)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Homo sapiens)
2MACA-CoA [mitochondrial matrix]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Branched-chain amino acid catabolism (Mus musculus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Mus musculus)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Mus musculus)
2MACA-CoA [mitochondrial matrix]
Metabolism (Plasmodium falciparum)
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Branched-chain amino acid catabolism (Plasmodium falciparum)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)
2MACA-CoA [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Branched-chain amino acid catabolism (Rattus norvegicus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Rattus norvegicus)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Rattus norvegicus)
2MACA-CoA [mitochondrial matrix]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Branched-chain amino acid catabolism (Sus scrofa)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Sus scrofa)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Sus scrofa)
2MACA-CoA [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Branched-chain amino acid catabolism (Xenopus tropicalis)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Xenopus tropicalis)
2MACA-CoA [mitochondrial matrix]
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Xenopus tropicalis)
2MACA-CoA [mitochondrial matrix]
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Xenopus tropicalis)
2MACA-CoA [mitochondrial matrix]
External Reference Information
External Reference
2-methylacetoacetyl-CoA(4-) [ChEBI:57335]
Participates
as an input of
ACAT1 mutants don't synthesize propionyl-CoA or acetyl-CoA (Homo sapiens)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Gallus gallus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Xenopus tropicalis)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Dictyostelium discoideum)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Caenorhabditis elegans)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Drosophila melanogaster)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Gallus gallus)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Xenopus tropicalis)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Danio rerio)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Sus scrofa)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Bos taurus)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Canis familiaris)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Rattus norvegicus)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Mus musculus)
alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Homo sapiens)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)
as an output of
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Dictyostelium discoideum)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Caenorhabditis elegans)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Drosophila melanogaster)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Gallus gallus)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Xenopus tropicalis)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Danio rerio)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Sus scrofa)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Bos taurus)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Canis familiaris)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Mus musculus)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Homo sapiens)
alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Rattus norvegicus)
Cross References
COMPOUND
C03344
ZINC
000096077640
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