Reactome | ROS [cytosol]

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ROS [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[BlackBoxEvent:R-CEL-1250280] ROS oxidize thioredoxin - Caenorhabditis elegans [BlackBoxEvent:R-DME-1250280] ROS oxidize thioredoxin - Drosophila melanogaster [BlackBoxEvent:R-GGA-1250280] ROS oxidize thioredoxin - Gallus gallus [BlackBoxEvent:R-DRE-1250280] ROS oxidize thioredoxin - Danio rerio [BlackBoxEvent:R-SSC-1250280] ROS oxidize thioredoxin - Sus scrofa [BlackBoxEvent:R-BTA-1250280] ROS oxidize thioredoxin - Bos taurus [BlackBoxEvent:R-CFA-1250280] ROS oxidize thioredoxin - Canis familiaris [BlackBoxEvent:R-RNO-1250280] ROS oxidize thioredoxin - Rattus norvegicus [BlackBoxEvent:R-MMU-1250280] ROS oxidize thioredoxin - Mus musculus [BlackBoxEvent:R-HSA-1250280] ROS oxidize thioredoxin - Homo sapiens [Reaction:R-PFA-9857090] Reactive oxygen species oxidize DNAJA1 - Plasmodium falciparum [Reaction:R-SCE-9857090] Reactive oxygen species oxidize DNAJA1 - Saccharomyces cerevisiae [Reaction:R-SPO-9857090] Reactive oxygen species oxidize DNAJA1 - Schizosaccharomyces pombe [Reaction:R-DDI-9857090] Reactive oxygen species oxidize DNAJA1 - Dictyostelium discoideum [Reaction:R-CEL-9857090] Reactive oxygen species oxidize DNAJA1 - Caenorhabditis elegans [Reaction:R-DME-9857090] Reactive oxygen species oxidize DNAJA1 - Drosophila melanogaster [Reaction:R-GGA-9857090] Reactive oxygen species oxidize DNAJA1 - Gallus gallus [Reaction:R-XTR-9857090] Reactive oxygen species oxidize DNAJA1 - Xenopus tropicalis [Reaction:R-DRE-9857090] Reactive oxygen species oxidize DNAJA1 - Danio rerio [Reaction:R-SSC-9857090] Reactive oxygen species oxidize DNAJA1 - Sus scrofa [Reaction:R-BTA-9857090] Reactive oxygen species oxidize DNAJA1 - Bos taurus [Reaction:R-CFA-9857090] Reactive oxygen species oxidize DNAJA1 - Canis familiaris [Reaction:R-RNO-9857090] Reactive oxygen species oxidize DNAJA1 - Rattus norvegicus [Reaction:R-MMU-9857090] Reactive oxygen species oxidize DNAJA1 - Mus musculus [Reaction:R-HSA-9857090] Reactive oxygen species oxidize DNAJA1 - Homo sapiens [Reaction:R-CEL-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Caenorhabditis elegans [Reaction:R-DME-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Drosophila melanogaster [Reaction:R-GGA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Gallus gallus [Reaction:R-DRE-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Danio rerio [Reaction:R-SSC-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Sus scrofa [Reaction:R-BTA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Bos taurus [Reaction:R-CFA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Canis familiaris [Reaction:R-RNO-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Rattus norvegicus [Reaction:R-MMU-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Mus musculus [Reaction:R-HSA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Homo sapiens
created	[InstanceEdit:1250252] Jupe, S, 2011-04-15
dbId	1250243
displayName	ROS [cytosol]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9619952] Wu, G, 2018-09-19
name	ROS reactive oxygen species
negativelyRegulates	[NegativeRegulation:9708559] Negative regulation by 'ROS [cytosol]'
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-3225856] Positive gene expression regulation by 'ROS [cytosol]' [PositiveRegulation:9665172] Positive regulation by 'ROS [cytosol]'
producedByEvent	[BlackBoxEvent:R-HSA-3223236] RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:26523] reactive oxygen species [ChEBI:26523]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-1250243
updateTrackers	[UpdateTracker:9892108] Update Tracker - [SimpleEntity:1250243] ROS [cytosol] - v52:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9892108] Update Tracker - [SimpleEntity:1250243] ROS [cytosol] - v52:[modifyName]
(regulator)	[NegativeRegulation:9708559] Negative regulation by 'ROS [cytosol]' [PositiveGeneExpressionRegulation:R-HSA-3225856] Positive gene expression regulation by 'ROS [cytosol]' [PositiveRegulation:9665172] Positive regulation by 'ROS [cytosol]'
(requiredInputComponent)	[BlackBoxEvent:R-HSA-9841244] Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species
(input)	[Reaction:R-PFA-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-SCE-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-SPO-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-DDI-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-CEL-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-DME-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-GGA-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-XTR-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-DRE-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-SSC-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-BTA-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-CFA-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-RNO-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-MMU-9857090] Reactive oxygen species oxidize DNAJA1 [Reaction:R-HSA-9857090] Reactive oxygen species oxidize DNAJA1 [BlackBoxEvent:R-CEL-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-DME-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-GGA-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-DRE-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-SSC-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-BTA-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-CFA-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-RNO-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-MMU-1250280] ROS oxidize thioredoxin [BlackBoxEvent:R-HSA-1250280] ROS oxidize thioredoxin [Reaction:R-CEL-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-DME-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-GGA-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-DRE-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-SSC-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-BTA-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-CFA-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-RNO-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-MMU-3225851] ROS oxidize thioredoxin and activate MAP3K5 [Reaction:R-HSA-3225851] ROS oxidize thioredoxin and activate MAP3K5
(output)	[BlackBoxEvent:R-HSA-3223236] RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)

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