Reactome | Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

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Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis Show undefined attributes

author	[Person:9686454] Petrie, EJ [Person:9686476] Sandow, JJ [Person:9686466] Jacobsen, AV [Person:9676803] Smith, BJ [Person:9686451] Griffin, MDW [Person:5364117] Lucet, IS [Person:9686473] Dai, W [Person:5364098] Young, SN [Person:9686126] Tanzer, MC [Person:9686478] Wardak, A [Person:9686456] Liang, LY [Person:9686460] Cowan, AD [Person:5364228] Hildebrand, JM [Person:9686445] Kersten, WJA [Person:9686477] Lessene, G [Person:141939] Silke, J [Person:5364146] Czabotar, PE [Person:5364137] Webb, AI [Person:5364059] Murphy, JM
created	[InstanceEdit:9686457] Shamovsky, Veronica, 2020-05-01
dbId	9686453
displayName	Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
journal	Nat Commun
pages	2422
pubMedIdentifier	29930286
schemaClass	LiteratureReference
title	Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
url	http://www.ncbi.nlm.nih.gov/pubmed/29930286
volume	9
year	2018

Referrals

(literatureReference)

[Pathway:R-HSA-5675482] Regulation of necroptotic cell death
[Summation:9687636] Recombinant pseudokinase mixed lineage kinase domain-like (M...
[Reaction:R-HSA-9687625] ATP binds MLKL
[Summation:9793449] Exogenous stimuli provoke assembly of the receptor-interacti...
[Summation:5357788] Mixed lineage kinase domain-like protein (MLKL) was found to...
[Polymerisation:R-HSA-5357927] MLKL oligomerizes
[RegulationReference:9692647] Negative regulation by '(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol]' Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
[Polymer:R-HSA-5357857] p-T357,S358-MLKL oligomer [cytosol]
[Summation:5357947] Receptor-interacting serine/threonine-protein kinase 3 (RIPK...
[Summation:5357754] Exogenous stimuli provoke assembly of the receptor-interacti...

(author)

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