Reactome | Czabotar, PE

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Czabotar, PE Show undefined attributes

created	[InstanceEdit:5364231] Shamovsky, V, 2014-04-21
dbId	5364146
displayName	Czabotar, PE
firstname	Peter E
initial	PE
publications	[LiteratureReference:9697387] The Structural Basis of Necroptotic Cell Death Signaling [LiteratureReference:5364089] The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism [LiteratureReference:9820389] Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling [LiteratureReference:9686475] The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis [LiteratureReference:9687627] Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL [LiteratureReference:9820400] Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis [LiteratureReference:9697389] Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues [LiteratureReference:9697409] Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies [LiteratureReference:9686472] Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death [LiteratureReference:9686453] Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis [LiteratureReference:9710645] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
schemaClass	Person
surname	Czabotar

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