Vav interacts directly with PIP2 and PIP3, with a fivefold s...

created [InstanceEdit:434636] Jupe, S, 2009-09-02
dbId 434631
displayName Vav interacts directly with PIP2 and PIP3, with a fivefold s...
literatureReference
schemaClass Summation
text Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.
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