Reactome | The dimerization of Tie2 leads to autophosphorylation and ac...

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created	[InstanceEdit:210879] Garapati, P V, 2008-01-17 14:13:36
dbId	210876
displayName	The dimerization of Tie2 leads to autophosphorylation and ac...
literatureReference	[LiteratureReference:204768] Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt [LiteratureReference:210864] A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function
modified	[InstanceEdit:211548] Garapati, P V, 2008-02-05 13:52:09
schemaClass	Summation
text	The dimerization of Tie2 leads to autophosphorylation and activation of its kinase domain. There are multiple tyrosine phosphorylation sites in the Tie2 kinase domain. The phosphorylated tyrosine residues provide the interaction site for the SH2 domains of other downstream signaling molecules like PI3K, Grb2, SHP2 etc.

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