Reactome | FGFR3c binds to FGF

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FGFR3c binds to FGF Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:190262] de Bono, B, 2006-12-18 16:06:13
dbId	190261
displayName	FGFR3c binds to FGF
eventOf	[Pathway:R-HSA-190372] FGFR3c ligand binding and activation - Homo sapiens
followingEvent	[Reaction:R-HSA-190388] Autocatalytic phosphorylation of FGFR3c - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-189913] FGFR3c [plasma membrane] 2 × [DefinedSet:R-HSA-189955] FGFR3c-binding FGFs [extracellular region] [SimpleEntity:R-ALL-190915] HS [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:190251] Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. [LiteratureReference:191519] Structural basis for fibroblast growth factor receptor activation
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	FGFR3c binds to FGF
orthologousEvent	[Reaction:R-CEL-190261] FGFR3c binds to FGF - Caenorhabditis elegans [Reaction:R-DME-190261] FGFR3c binds to FGF - Drosophila melanogaster [Reaction:R-GGA-190261] FGFR3c binds to FGF - Gallus gallus [Reaction:R-DRE-190261] FGFR3c binds to FGF - Danio rerio [Reaction:R-BTA-190261] FGFR3c binds to FGF - Bos taurus [Reaction:R-CFA-190261] FGFR3c binds to FGF - Canis familiaris [Reaction:R-RNO-190261] FGFR3c binds to FGF - Rattus norvegicus [Reaction:R-MMU-190261] FGFR3c binds to FGF - Mus musculus
output	[Complex:R-HSA-190234] FGFR3c homodimer bound to FGF [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-480515] Expression of FGF2 - Homo sapiens [BlackBoxEvent:R-HSA-8851632] GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region - Homo sapiens
regulatedBy	[Requirement:R-HSA-190316] Requirement by 'HS [extracellular region]'
releaseDate	2007-02-28
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-190261
summation	[Summation:191578] In this reaction, FGF receptor in the plasma membrane binds ...

Referrals

(hasEvent)	[Pathway:R-HSA-190372] FGFR3c ligand binding and activation
(precedingEvent)	[Reaction:R-HSA-190388] Autocatalytic phosphorylation of FGFR3c