Reactome | phospho-vav3 [cytosol]

phospho-vav3 [cytosol]

Stable Identifier

R-XTR-442287

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

p-Y173-VAV3, F6USI5

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - EPH-Ephrin signaling (Xenopus tropicalis)
      - EPH-ephrin mediated repulsion of cells (Xenopus tropicalis)
        
        SFKs phosphorylate VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        phospho-vav3 [cytosol] (Xenopus tropicalis)

Immune System (Xenopus tropicalis)

- Innate Immune System (Xenopus tropicalis)
  - Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
    - FCERI mediated MAPK activation (Xenopus tropicalis)
      - Autophosphorylation of PAK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-VAV family [cytosol] (Xenopus tropicalis)
        
        phospho-vav3 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-VAV family [cytosol] (Xenopus tropicalis)
        
        phospho-vav3 [cytosol] (Xenopus tropicalis)
      - Phosphorylation and activation of VAV (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-VAV family [cytosol] (Xenopus tropicalis)
        
        phospho-vav3 [cytosol] (Xenopus tropicalis)
      - Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-VAV family [cytosol] (Xenopus tropicalis)
        
        phospho-vav3 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-VAV family [cytosol] (Xenopus tropicalis)
        
        phospho-vav3 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by VEGF (Xenopus tropicalis)
    - VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
      - Src kinases phosphorylate VAV (Xenopus tropicalis)
        
        p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-VAV family [cytosol] (Xenopus tropicalis)
        
        phospho-vav3 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6USI5

Gene Names

vav3

Reference Genes

BioGPS Gene:100493918 vav3

ENSEMBL:ENSXETG00000009944

Monarch:100493918 vav3

NCBI Gene:100493918 vav3

UCSC:F6USI5 vav3

Reference Transcript

RefSeq:XM_012962510.3 vav3

Other Identifiers

100493918

GO:0002768

GO:0005085

GO:0005737

GO:0005886

GO:0007165

GO:0007264

GO:0008270

GO:0016477

GO:0035556

GO:0046872

GO:0048870

GO:0051897

Participates

as a component of

as a member of

p-VAV family [cytosol] (Xenopus tropicalis)

Other forms of this molecule

vav3 [cytosol]

Inferred From

p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)

p-Y173-VAV3 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 173 (in Homo sapiens)

Coordinate

173

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_012817964.1

ENSEMBL

ENSXETG00000009944, ENSXETT00000021911, ENSXETP00000021911

Xenbase

XB-GENE-6075609