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p-Y173-VAV3 [cytosol]
Stable Identifier
R-HSA-442287
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-VAV3(Y173), Guanine nucleotide exchange factor VAV3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
SFKs phosphorylate VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
VAV3 is a GEF for Rho/Rac family kinases (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y348-SYK phosphorylates VAV family (Homo sapiens)
p-Y348-SYK:p-VAV family [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Activation of RAC1 by VAV2/3 (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Phosphorylation of VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
Src kinases phosphorylate VAV (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
PAK1-3 autophosphorylates (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
PAK1-3 dimer disassociates (Homo sapiens)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
RAC1 binds PAK1-3 (Homo sapiens)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-Y173-VAV3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKW4 VAV3
Gene Names
VAV3
Chain
chain:1-847
Reference Genes
BioGPS Gene:10451 VAV3
COSMIC (genes):VAV3 VAV3
CTD Gene:10451 VAV3
dbSNP Gene:10451 VAV3
ENSEMBL:ENSG00000134215 VAV3
HGNC:12659 VAV3
KEGG:hsa:10451 VAV3
Monarch:10451 VAV3
NCBI Gene:10451 VAV3
OMIM:605541 VAV3
UCSC:Q9UKW4 VAV3
Reference Transcript
RefSeq:XM_005270360.2 VAV3
RefSeq:NM_006113.4 VAV3
RefSeq:NM_001079874.1 VAV3
Other Identifiers
10451
11731655_a_at
11731656_a_at
11731657_s_at
11743933_a_at
11752220_a_at
11763401_a_at
16690341
16690343
218806_PM_s_at
218806_s_at
218807_PM_at
218807_at
224221_PM_s_at
224221_s_at
2426386
2426387
2426388
2426389
2426390
2426391
2426392
2426393
2426394
2426395
2426396
2426397
2426399
2426401
2426403
2426404
2426405
2426406
2426410
2426415
2426419
2426427
2426433
2426436
2426437
2426445
2426446
2426457
2426458
2426459
2426460
2426461
2426462
2426464
2426465
2426466
2426467
2426468
2426471
2426473
2426475
2426479
2426480
2426481
2426496
2426504
2426505
2426507
2426508
51289_at
51291_at
7918153
7918157
A_24_P7950
GE62631
GO:0001525
GO:0001772
GO:0002376
GO:0005085
GO:0005096
GO:0005154
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006906
GO:0006974
GO:0007166
GO:0007229
GO:0007264
GO:0008361
GO:0009410
GO:0016477
GO:0030031
GO:0030032
GO:0030168
GO:0030593
GO:0030890
GO:0035556
GO:0038095
GO:0038096
GO:0043087
GO:0045785
GO:0046872
GO:0048870
GO:0050853
GO:0051056
GO:0051897
GO:0061024
GO:0098772
HMNXSV003009437
HMNXSV003051828
HMNXSV003054935
ILMN_1657679
ILMN_2290068
ILMN_2399463
PH_hs_0013714
TC01002939.hg
TC01002940.hg
g4416405_3p_a_at
g4416407_3p_a_at
g7262390_3p_at
Participates
as a member of
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
as a candidate of
p-VAV family [cytosol] (Homo sapiens)
Other forms of this molecule
VAV3 [cytosol]
Inferred To
phospho-VAV3 [cytosol]
(Bos taurus)
phospho-VAV3 [cytosol]
(Canis familiaris)
phospho-VAV3 [cytosol]
(Gallus gallus)
phospho-Vav [cytosol]
(Drosophila melanogaster)
phospho-vav-1 [cytosol]
(Caenorhabditis elegans)
phospho-Vav3 [cytosol]
(Mus musculus)
phospho-Vav3 [cytosol]
(Rattus norvegicus)
phospho-vav3 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 173
Coordinate
173
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_006104.4
,
XP_005270417.1
,
NP_001073343.1
ENSEMBL
ENST00000370056
,
ENSP00000359073
,
ENST00000415432
,
ENSP00000432540
,
ENSP00000394897
,
ENST00000527011
OpenTargets
ENSG00000134215
HPA
ENSG00000134215-VAV3
PRO
Q9UKW4
Pharos - Targets
Q9UKW4
HMDB Protein
HMDBP08615
PDB
2D86
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.848
8
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.556
3
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
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