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RBX1-CUL2-EloB,C-VHL [cytosol]
Stable Identifier
R-SSC-976093
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to hypoxia (Sus scrofa)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Sus scrofa)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
VBC complex (with or without LIMD1) [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Polyubiquitination of substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Release of E3 from polyubiquitinated substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CUL2 [cytosol]
(Sus scrofa)
RBX1 [cytosol]
(Sus scrofa)
VBC complex [cytosol]
(Sus scrofa)
Participates
as a member of
VBC complex (with or without LIMD1) [cytosol] (Sus scrofa)
as a component of
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
Inferred From
RBX1-CUL2-EloB,C-VHL [cytosol]
(Homo sapiens)
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