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VBC complex [cytosol]
Stable Identifier
R-SSC-390483
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to hypoxia (Sus scrofa)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Sus scrofa)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
VBC complex (with or without LIMD1) [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Polyubiquitination of substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Release of E3 from polyubiquitinated substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Neddylation (Sus scrofa)
26S proteasome degrades HIFalpha (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
VBC complex [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
ELOB [cytosol]
(Sus scrofa)
ELOC [cytosol]
(Sus scrofa)
Ghost homologue of VHL [cytosol]
(Sus scrofa)
Participates
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
RBX1-CUL2-EloB,C-VHL [cytosol] (Sus scrofa)
Inferred From
VBC complex [cytosol]
(Homo sapiens)
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