Reactome | phospho-p-S5(CTD)-POLR2A [nucleoplasm]

phospho-p-S5(CTD)-POLR2A [nucleoplasm]

Stable Identifier

R-SSC-77100

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

I3LJR4

Locations in the PathwayBrowser

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Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - RNA Pol II CTD phosphorylation and interaction with CE (Sus scrofa)
    - Activation of GT (Sus scrofa)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Pre-transcription Events (Sus scrofa)
    - Abortive termination of early transcription elongation by DSIF:NELF (Sus scrofa)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Transcription Elongation (Sus scrofa)
    - Formation of RNA Pol II elongation complex (Sus scrofa)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - Formation of the Early Elongation Complex (Sus scrofa)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
      - Formation of DSIF:NELF:early elongation complex (Sus scrofa)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Internal Methylation of mRNA (Sus scrofa)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
- mRNA Capping (Sus scrofa)
  - Activation of GT (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - Capping complex formation (Sus scrofa)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (initial) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - Dissociation of transcript with 5'-GMP from GT (Sus scrofa)
    - Capping complex (GpppN..) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - Formation of the CE:GMP intermediate complex (Sus scrofa)
    - Capping complex (intermediate) [nucleoplasm] (Sus scrofa)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Sus scrofa)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (hydrolyzed) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)
    - Capping complex (hydrolyzed) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (initial) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Sus scrofa)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)
    - Capping complex (intermediate) [nucleoplasm] (Sus scrofa)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Sus scrofa)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (GpppN..) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-p-S5(CTD)-POLR2A [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3LJR4

Reference Genes

ENSEMBL:ENSSSCG00000028278.4

UCSC:I3LJR4

Other Identifiers

100737040

GO:0000428

GO:0000791

GO:0001046

GO:0003676

GO:0003677

GO:0003824

GO:0003899

GO:0005634

GO:0005654

GO:0005665

GO:0005694

GO:0005737

GO:0006351

GO:0006366

GO:0016071

GO:0016740

GO:0016779

GO:0016787

GO:0031981

GO:0034062

GO:0042789

GO:0046872

GO:0140098

Participates

as a component of

Other forms of this molecule

POLR2A [nucleoplasm]

phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]

phospho-p-3S-POLR2A [nucleoplasm]

phospho-Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]

phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm]

phospho-p-S2,S7(CTD)-POLR2A [nucleoplasm]

phospho-p-S2(CTD)-POLR2A [nucleoplasm]

Inferred From

p-S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 1843 (in Homo sapiens)

Coordinate

1843

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1850 (in Homo sapiens)

Coordinate

1850

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1857 (in Homo sapiens)

Coordinate

1857

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1864 (in Homo sapiens)

Coordinate

1864

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1871 (in Homo sapiens)

Coordinate

1871

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1878 (in Homo sapiens)

Coordinate

1878

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1892 (in Homo sapiens)

Coordinate

1892

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1899 (in Homo sapiens)

Coordinate

1899

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1906 (in Homo sapiens)

Coordinate

1906

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1913 (in Homo sapiens)

Coordinate

1913

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1920 (in Homo sapiens)

Coordinate

1920

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1927 (in Homo sapiens)

Coordinate

1927

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1934 (in Homo sapiens)

Coordinate

1934

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

ENSEMBL

ENSSSCP00000024326, ENSSSCT00000029425, ENSSSCG00000028278

VGNC

91646

PDB

9G0A, 7PKS, 9FYX, 8RBZ, 6GML, 7B7U, 6EXV, 6GMH

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