Reactome | POLR2A [nucleoplasm]

DNA Repair (Sus scrofa)

- Nucleotide Excision Repair (Sus scrofa)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Sus scrofa)
    - Formation of TC-NER Pre-Incision Complex (Sus scrofa)
      - RNA Pol II initiates transcription from damaged DNA template (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- Gene Silencing by RNA (Sus scrofa)
  - Transcriptional regulation by small RNAs (Sus scrofa)
    - AGO1,2:small RNA complexes interact with chromatin (Sus scrofa)
      - AGO1,2:miRNA:chromatin:RNA pol II [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - RNA Pol II CTD phosphorylation and interaction with CE (Sus scrofa)
    - Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Sus scrofa)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
    - Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Pre-transcription Events (Sus scrofa)
    - Abortive Initiation After Second Transition (Sus scrofa)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
    - Fall Back to Closed Pre-initiation Complex (Sus scrofa)
      - pol II closed pre-initiation complex [nucleoplasm] (Sus scrofa)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - pol II open pre-initiation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Transcription Initiation And Promoter Clearance (Sus scrofa)
    - RNA Polymerase II Promoter Escape (Sus scrofa)
      - Addition of Nucleotides 5 through 9 on the growing Transcript (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - Addition of nucleotides between position +11 and +30 (Sus scrofa)
        
        Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - Addition of the third nucleotide on the nascent transcript (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II transcription complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - Unwinding DNA for the nascent transcript (Sus scrofa)
        
        pol II transcription complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - Unwinding of DNA for the Nascent Transcript: Second Transition (Sus scrofa)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Polymerase II Promoter Opening: First Transition (Sus scrofa)
      - pol II closed pre-initiation complex [nucleoplasm] (Sus scrofa)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - pol II open pre-initiation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Polymerase II Transcription Initiation (Sus scrofa)
      - NTP Binds Active Site of RNA Polymerase II (Sus scrofa)
        
        Pol II initiation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II open pre-initiation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - Newly Formed Phosphodiester Bond Stabilized and PPi Released (Sus scrofa)
        
        Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        pol II transcription complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Sus scrofa)
        
        Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        Pol II initiation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (Sus scrofa)
    - Binding of TFIIE to the growing preinitiation complex (Sus scrofa)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] (Sus scrofa)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
    - Formation of the closed pre-initiation complex (Sus scrofa)
      - pol II closed pre-initiation complex [nucleoplasm] (Sus scrofa)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] (Sus scrofa)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
    - Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Sus scrofa)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
  - RNA polymerase II transcribes snRNA genes (Sus scrofa)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Sus scrofa)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Sus scrofa)
      - RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by FGFR (Sus scrofa)
    - Signaling by FGFR2 (Sus scrofa)
      - FGFR2 alternative splicing (Sus scrofa)
        
        PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Sus scrofa)
        
        FGFR2 IIIc-specific splicing complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Sus scrofa)
        
        POLR2A [nucleoplasm] (Sus scrofa)