Reactome | TMED2 [endoplasmic reticulum membrane]

TMED2 [endoplasmic reticulum membrane]

Stable Identifier

R-SSC-5689480

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

endoplasmic reticulum membrane

Synonyms

TMED2, A0A8W4FFC7

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Asparagine N-linked glycosylation (Sus scrofa)
    - Transport to the Golgi and subsequent modification (Sus scrofa)
      - ER to Golgi Anterograde Transport (Sus scrofa)
        
        COPII-mediated vesicle transport (Sus scrofa)
        
        Inner coat assembly and cargo binding (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        Loss of SAR1B GTPase (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        Vesicle budding (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        Cargo concentration in the ER (Sus scrofa)
        
        Inner coat assembly and cargo binding (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer binds GPI anchored proteins (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - ER to Golgi Anterograde Transport (Sus scrofa)
    - COPII-mediated vesicle transport (Sus scrofa)
      - Inner coat assembly and cargo binding (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
      - Loss of SAR1B GTPase (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
      - Vesicle budding (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
    - Cargo concentration in the ER (Sus scrofa)
      - Inner coat assembly and cargo binding (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
      - TMED2:TMED10 tetramer binds GPI anchored proteins (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Sus scrofa)
    - Golgi-to-ER retrograde transport (Sus scrofa)
      - COPI-dependent Golgi-to-ER retrograde traffic (Sus scrofa)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Sus scrofa)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Sus scrofa)
        
        Golgi-to-ER cargo [endoplasmic reticulum membrane] (Sus scrofa)
        
        SURF4:p24 complex [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 dimer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        p24 dimers [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 dimer [endoplasmic reticulum membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A8W4FFC7

Gene Names

TMED2

Reference Genes

ENSEMBL:ENSSSCG00000009772.4

UCSC:A0A8W4FFC7 TMED2

Other Identifiers

100625917

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0006886

GO:0006888

GO:0007030

GO:0016020

GO:0016192

GO:0030134

GO:0031410

GO:0033116

GO:0043226

Ssc.4554.1.S1_at

Participates

as a component of

Other forms of this molecule

TMED2 [ER to Golgi transport vesicle membrane]

TMED2 [Golgi membrane]

TMED2 [transport vesicle]

TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Inferred From

TMED2 [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCG00000009772, ENSSSCT00000091916, ENSSSCP00000077573

Cite Us!