Reactome | TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-SSC-1911531

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

TMED2, A0A8W4FFC7

Locations in the PathwayBrowser

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Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Asparagine N-linked glycosylation (Sus scrofa)
    - Transport to the Golgi and subsequent modification (Sus scrofa)
      - ER to Golgi Anterograde Transport (Sus scrofa)
        
        COPI-mediated anterograde transport (Sus scrofa)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        ARFGAPs stimulate ARF GTPase activity (Sus scrofa)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        COPII-mediated vesicle transport (Sus scrofa)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - ER to Golgi Anterograde Transport (Sus scrofa)
    - COPI-mediated anterograde transport (Sus scrofa)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
      - ARFGAPs stimulate ARF GTPase activity (Sus scrofa)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
    - COPII-mediated vesicle transport (Sus scrofa)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A8W4FFC7

Gene Names

TMED2

Reference Genes

ENSEMBL:ENSSSCG00000009772.4

Other Identifiers

100625917

GO:0001701

GO:0001756

GO:0001843

GO:0001892

GO:0001893

GO:0001947

GO:0005109

GO:0005119

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0006886

GO:0006954

GO:0007029

GO:0007030

GO:0008104

GO:0009306

GO:0010628

GO:0022414

GO:0023052

GO:0032525

GO:0035264

GO:0036211

GO:0036342

GO:0036499

GO:0043226

GO:0043231

GO:0045879

GO:0048598

GO:0048856

GO:0060670

GO:0060716

GO:0060717

GO:0061024

GO:0072595

GO:0072659

GO:0090158

GO:1903077

GO:1903912

GO:1905069

GO:2000638

Ssc.4554.1.S1_at

Participates

as a component of

This entity regulates

Negatively

Mature NOTCH heterodimer traffics to the plasma membrane (Sus scrofa)

Other forms of this molecule

TMED2 [transport vesicle]

TMED2 [Golgi membrane]

TMED2 [ER to Golgi transport vesicle membrane]

TMED2 [endoplasmic reticulum membrane]

Inferred From

TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000086598

Ensembl

ENSSSCG00000009772, ENSSSCT00000091916, ENSSSCP00000077573

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