CYP8B1 12-hydroxylates 4CHOL7a,27DONE

Stable Identifier
R-SSC-193845
Type
Reaction [transition]
Species
Sus scrofa
Compartment
Synonyms
4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, 4-Cholesten-7alpha,27-diol-3-one + NADPH + H+ + O2 => 4-Cholesten-7alpha,12alpha,27-triol-3-one + NADP+ + H2O
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This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Participants
Participates
Catalyst Activity

7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity of CYP8B1 [endoplasmic reticulum membrane]

Inferred From
Created
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