Reactome | CDC6 [nucleoplasm]

CDC6 [nucleoplasm]

Stable Identifier

R-SCE-68542

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P09119

Locations in the PathwayBrowser

Expand all

Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle Checkpoints (Saccharomyces cerevisiae)
  - G2/M Checkpoints (Saccharomyces cerevisiae)
    - Activation of ATR in response to replication stress (Saccharomyces cerevisiae)
      - Loading of claspin onto DNA during replication origin firing (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - Mitotic G1 phase and G1/S transition (Saccharomyces cerevisiae)
    - G1/S Transition (Saccharomyces cerevisiae)
      - Activation of the pre-replicative complex (Saccharomyces cerevisiae)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)
        
        MCM10:pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)

DNA Replication (Saccharomyces cerevisiae)

- DNA Replication Pre-Initiation (Saccharomyces cerevisiae)
  - Activation of the pre-replicative complex (Saccharomyces cerevisiae)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
      - MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
    - Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
    - DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
    - DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)
      - MCM10:pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
      - pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
  - Assembly of the pre-replicative complex (Saccharomyces cerevisiae)
    - CDC6 association with the ORC:origin complex (Saccharomyces cerevisiae)
      - CDC6 association with ORC(1-6) at replication origins (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDC6 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P09119 CDC6

Gene Names

CDC6, YJL194W, J0347

Chain

chain:1-513

Reference Genes

BioGPS Gene:853244 CDC6

KEGG:sce:YJL194W CDC6

Monarch:853244 CDC6

NCBI Gene:853244 CDC6

UCSC:P09119 CDC6

Reference Transcript

RefSeq:NM_001181627.1 CDC6

Other Identifiers

853244

GO:0000082

GO:0000166

GO:0000278

GO:0003674

GO:0003682

GO:0003688

GO:0003924

GO:0004861

GO:0005515

GO:0005524

GO:0005525

GO:0005575

GO:0005634

GO:0005654

GO:0005656

GO:0005694

GO:0005737

GO:0006260

GO:0006267

GO:0006270

GO:0008150

GO:0016787

GO:0016887

GO:0030174

GO:0030234

GO:0031261

GO:0031938

GO:0033314

GO:0043167

GO:0051052

GO:0051301

GO:0051726

GO:0140530

Participates

as a component of

as an input of

CDC6 association with ORC(1-6) at replication origins (Saccharomyces cerevisiae)

Other forms of this molecule

phospho-p-CDC6 [cytosol]

phospho-p-CDC6 [nucleoplasm]

yCDC6 [nucleoplasm]

Inferred From

CDC6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_012341.1

ENSEMBL

YJL194W, YJL194W_mRNA, YJL194W

PRO

P09119

PDB

7TJJ, 7TJK, 7TJI, 6WGC, 6WGI, 7MCA, 6WGG, 9BCX, 7TJH, 5V8F

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32833 ORC2	2	yORC2 [nucleoplasm] (R-SCE-9749316) ORC2 [nucleoplasm] (R-SCE-68405)	0.77	5
UniProt:P38826 ORC6	1	yORC6 [nucleoplasm] (R-SCE-9749321)	0.77	5
UniProt:P50874 ORC5	2	yORC5 [nucleoplasm] (R-SCE-9749322) ORC5 [nucleoplasm] (R-SCE-68516)	0.77	5
UniProt:P54784 ORC1	6	ORC1 [nucleoplasm] (R-SCE-68522) yORC1 [nucleoplasm] (R-SCE-9749323) ORC1 [cytosol] (R-SCE-113840) phospho-p-S,T-ORC1 [nucleoplasm] (R-SCE-68943) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-SCE-9032189) phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-SCE-9032195)	0.77	5
UniProt:P54790 ORC3	2	yORC3 [nucleoplasm] (R-SCE-9749325) ORC3 [nucleoplasm] (R-SCE-68513)	0.77	5
UniProt:P54791 ORC4	2	yORC4 [nucleoplasm] (R-SCE-9749319) ORC4 [nucleoplasm] (R-SCE-68519)	0.77	5
UniProt:P29469 MCM2	2	MCM2 [nucleoplasm] (R-SCE-68557) yMcm2 [nucleoplasm] (R-SCE-169497)	0.766	6
UniProt:P24279 MCM3	2	MCM3 [nucleoplasm] (R-SCE-68546) yMcm3 [nucleoplasm] (R-SCE-169513)	0.666	4
UniProt:P53091 MCM6	2	MCM6 [nucleoplasm] (R-SCE-68553) yMcm6 [nucleoplasm] (R-SCE-169504)	0.606	3
UniProt:P29496 MCM5	2	MCM5 [nucleoplasm] (R-SCE-68551) yMcm5 [nucleoplasm] (R-SCE-169511)	0.606	3
UniProt:P38132 MCM7	2	MCM7 [nucleoplasm] (R-SCE-68555) yMcm7 [nucleoplasm] (R-SCE-169505)	0.606	3
UniProt:P47112 TAH11	1	yCDT1 [nucleoplasm] (R-SCE-9749306)	0.606	3
UniProt:P30665 MCM4	2	MCM4 [nucleoplasm] (R-SCE-68549) yMcm4 [nucleoplasm] (R-SCE-169496)	0.606	3
UniProt:P43603 LSB3			0.592	2
UniProt:P47068 BBC1			0.456	3

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