Reactome | MCM2 [nucleoplasm]

MCM2 [nucleoplasm]

Stable Identifier

R-SCE-68557

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P29469

Locations in the PathwayBrowser

Expand all

Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle Checkpoints (Saccharomyces cerevisiae)
  - G2/M Checkpoints (Saccharomyces cerevisiae)
    - Activation of ATR in response to replication stress (Saccharomyces cerevisiae)
      - Loading of claspin onto DNA during replication origin firing (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - Mitotic G1 phase and G1/S transition (Saccharomyces cerevisiae)
    - G1/S Transition (Saccharomyces cerevisiae)
      - Activation of the pre-replicative complex (Saccharomyces cerevisiae)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)
        
        MCM10:pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Mcm2-7 is phosphorylated by DDK (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        p-MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
  - S Phase (Saccharomyces cerevisiae)
    - Synthesis of DNA (Saccharomyces cerevisiae)
      - Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCM2 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P29469 MCM2

Gene Names

MCM2, YBL023C, YBL0438

Chain

chain:1-868

Reference Genes

BioGPS Gene:852258 MCM2

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YBL023C MCM2

KEGG Gene (Saccharomyces cerevisiae):YBL023C MCM2

Monarch:852258 MCM2

NCBI Gene:852258 MCM2

Reference Transcript

RefSeq:NM_001178263.1 MCM2

Other Identifiers

1776843_at

7384_at

852258

GO:0000166

GO:0000278

GO:0000347

GO:0000727

GO:0003674

GO:0003677

GO:0003678

GO:0003682

GO:0003688

GO:0003697

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005654

GO:0005656

GO:0005694

GO:0005737

GO:0005829

GO:0006260

GO:0006267

GO:0006268

GO:0006270

GO:0006271

GO:0006281

GO:0006310

GO:0006974

GO:0007049

GO:0008150

GO:0008270

GO:0016787

GO:0016887

GO:0017116

GO:0030174

GO:0031261

GO:0031298

GO:0032508

GO:0033043

GO:0042555

GO:0043138

GO:0043167

GO:0043596

GO:0046872

GO:0051052

GO:0071162

GO:0140657

GO:1902450

GO:1902975

GO:1905775

Participates

as an output of

Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)

as an input of

MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Saccharomyces cerevisiae)

as a component of

MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

yMcm2 [nucleoplasm]

Inferred From

MCM2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_009530.1

OpenTargets

ENSG00000073111

PRO

P29469

PDB

6U0M, 5U8T, 6PTO, 6SKO, 6HV9, 3JA8, 7V3U, 3JC5, 5V8F, 7PMK, 5BK4, 7PMN, 3JC6, 6WGG, 6WGF, 3JC7, 7V3V, 7PT6, 7PT7, 6RQC, 6EYC, 6WGI, 7W8G, 6PTJ, 7P5Z, 5XF8, 6F0L, 6PTN, 5U8S, 6SKL, 7P30

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30665 MCM4	2	MCM4 [nucleoplasm] (R-SCE-68549) yMcm4 [nucleoplasm] (R-SCE-169496)	0.939	15
UniProt:P29496 MCM5	2	MCM5 [nucleoplasm] (R-SCE-68551) yMcm5 [nucleoplasm] (R-SCE-169511)	0.879	8
UniProt:P24279 MCM3	2	MCM3 [nucleoplasm] (R-SCE-68546) yMcm3 [nucleoplasm] (R-SCE-169513)	0.855	8
UniProt:P53091 MCM6	2	MCM6 [nucleoplasm] (R-SCE-68553) yMcm6 [nucleoplasm] (R-SCE-169504)	0.839	7
UniProt:P38132 MCM7	2	MCM7 [nucleoplasm] (R-SCE-68555) yMcm7 [nucleoplasm] (R-SCE-169505)	0.839	7
UniProt:Q08032	1	CDC45 [nucleoplasm] (R-SCE-68563)	0.731	4
UniProt:P09119 CDC6	4	phospho-p-CDC6 [cytosol] (R-SCE-68583) phospho-p-CDC6 [nucleoplasm] (R-SCE-5661317) yCDC6 [nucleoplasm] (R-SCE-9749328) CDC6 [nucleoplasm] (R-SCE-68542)	0.667	4
UniProt:P47112 TAH11	1	yCDT1 [nucleoplasm] (R-SCE-9749306)	0.638	4
UniProt:Q08496 DIA2			0.613	4
UniProt:P11484	2	HSPA2 [cytosol] (R-SCE-3371408-4) HSPA2 [nucleoplasm] (R-SCE-912480-4)	0.564	2
UniProt:P32354	1	MCM10 [nucleoplasm] (R-SCE-68403)	0.547	2
UniProt:Q12306	5	SMT3 [cytosol] (R-SCE-4656941) SMT3 [nucleoplasm] (R-SCE-2990831) SMT3 [nucleoplasm] (R-SCE-877304) SMT3 [nucleoplasm] (R-SCE-3730616) SMT3 [nucleoplasm] (R-SCE-3730622)	0.524	2

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