NatC acetylates ARL3

Stable Identifier
R-SCE-6814089
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NatC acetylates ARL3
The NatC complex acetylates the amino-terminal methionine of ARL3, a ARF-like GTPase with roles in retrograde traffic at the Golgi membrane Acetylation and interaction with the membrane protein Sys1 are needed for the Golgi localization of ARL3 (Behnia et al, 2004; Setty et al, 2004).
Literature References
PubMed ID Title Journal Year
15077114 Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p

Setty, SR, Strochlic, TI, Tong, AH, Boone, C, Burd, CG

Nat. Cell Biol. 2004
15077113 Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p

Behnia, R, Panic, B, Whyte, JR, Munro, S

Nat. Cell Biol. 2004
Participants
Input
Output
Catalyst Activity

protein-N-terminal amino-acid acetyltransferase activity of NatC complex [cytosol]

Physical Entity
NatC complex [cytosol] (Saccharomyces cerevisiae)
Activity
protein-N-terminal amino-acid acetyltransferase activity (GO:0004596)
Orthologous Events
NatC acetylates ARFFRP1 (Homo sapiens)
Authored
Rothfels, K  (2015-11-09)
Reviewed
Gillespie, ME  (2016-02-02)
Created
Rothfels, K  (2015-11-25)
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