NatC acetylates ARFFRP1

Stable Identifier
R-HSA-6814090
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NatC acetylates ARFFRP1
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ARFRP1 is an ARF family member GTPase that recruits ARL1 to the trans-Golgi network to play roles in retrograde trafficking of proteins from the endolysosomal system. ARFRP1 is an atypical ARF family member in that it is not myristolated, but is instead acetylated at the amino-terminal methionine by the NatC complex. Acetylation is required for the interaction of ARFRP1 with SYS1, which contributes to its targeting to its TGN (Behnia et al, 2004; Setty et al, 2004).
Literature References
PubMed ID Title Journal Year
15077114 Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p

Setty, SR, Boone, C, Tong, AH, Strochlic, TI, Burd, CG

Nat. Cell Biol. 2004
15077113 Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p

Panic, B, Whyte, JR, Behnia, R, Munro, S

Nat. Cell Biol. 2004
Participants
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Output
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as an event of
Catalyst Activity

peptide alpha-N-acetyltransferase activity of NAA30:NAA35:NAA38 [cytosol]

Physical Entity
NAA30:NAA35:NAA38 [cytosol] (Homo sapiens)
Activity
peptide alpha-N-acetyltransferase activity (GO:0004596)
Inferred From
NatC acetylates ARL3 (Saccharomyces cerevisiae)
Authored
Rothfels, K  (2015-11-09)
Reviewed
Gillespie, ME  (2016-02-02)
Created
Rothfels, K  (2015-11-25)
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