Reactome | 5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast)

5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast)

Stable Identifier

R-SCE-429913

Type

Reaction [transition]

Species

Saccharomyces cerevisiae

Compartment

cytosol

ReviewStatus

5/5

General

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5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast)

The Xrn1 exoribonuclease hydrolyzes decapped mRNA from 5' to 3' and yields ribonucleotides having 5'-monophosphates. In yeast Xrn1 associates with the Lsm1-7 complex.

Literature References

PubMed ID	Title	Journal	Year
9315672	Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively Johnson, AW	Mol Cell Biol	1997
1398123	Characterization of the XRN1 gene encoding a 5'-->3' exoribonuclease: sequence data and analysis of disparate protein and mRNA levels of gene-disrupted yeast cells Larimer, FW, Hsu, CL, Maupin, MK, Stevens, A	Gene	1992
19111176	In vitro assays of 5' to 3'-exoribonuclease activity Pellegrini, O, Mathy, N, Condon, C, Benard, L	Methods Enzymol	2008

Participants

Input

Output

Catalyst Activity

5'-3' RNA exonuclease activity of XRN1_YEAST [cytosol]

Physical Entity

XRN1_YEAST [cytosol] (Saccharomyces cerevisiae)

Activity

5'-3' RNA exonuclease activity (GO:0004534)

Orthologous Events

5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)

Authored

May, B (2009-07-22)

Reviewed

Wilusz, J (2009-09-17)

Created

May, B (2009-07-24)

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