5' to 3' exoribonuclease hydrolyzes decapped mRNA

Stable Identifier
R-HSA-429845
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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5' to 3' exoribonuclease hydrolyzes decapped mRNA
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The XRN1 exoribonuclease hydrolyzes decapped mRNA from 5' to 3' and yields ribonucleotides having 5'-monophosphates. In yeast Xrn1 associates with the Lsm1-7 complex.
Literature References
PubMed ID Title Journal Year
14749774 The enzymes and control of eukaryotic mRNA turnover

Parker, R, Song, H

Nat Struct Mol Biol 2004
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
12515382 The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci

Ingelfinger, D, Arndt-Jovin, DJ, Lührmann, R, Achsel, T

RNA 2002
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J

Cell Biochem Biophys 2004
16299471 ARE-mRNA degradation requires the 5'-3' decay pathway

Stoecklin, G, Mayo, T, Anderson, P

EMBO Rep 2006
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
11283721 The cap-to-tail guide to mRNA turnover

Wilusz, CJ, Wormington, M, Peltz, SW

Nat Rev Mol Cell Biol 2001
Participants
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Catalyst Activity

5'-3' RNA exonuclease activity of XRN1 [cytosol]

Physical Entity
XRN1 [cytosol] (Homo sapiens)
Activity
5'-3' RNA exonuclease activity (GO:0004534)
Inferred From
5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast) (Saccharomyces cerevisiae)
Authored
May, B  (2009-07-22)
Reviewed
Wilusz, J  (2009-09-17)
Created
May, B  (2009-07-24)
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