p-S516-Arhgef7 activates Rac1

Stable Identifier
R-RNO-9619811
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-S516-Arhgef7 activates Rac1
In rat neurons, Camk1-mediated phosphorylation of Arhgef7 (Beta-Pix) at serine S516 enhances guanine nucleotide exchange factor (GEF) activity of Arhgef7, leading to Rac1 activation. Rac1 and its downstream effector Pak1 are involved in NMDA receptor activity-dependent synaptogenesis (Saneyoshi et al. 2013).
Literature References
PubMed ID Title Journal Year
18184567 Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex

Saneyoshi, T, Wayman, G, Fortin, D, Davare, M, Hoshi, N, Nozaki, N, Natsume, T, Soderling, TR

Neuron 2008
Participants
Input
Output
Catalyst Activity

guanyl-nucleotide exchange factor activity of Git1:p-S516-Arhgef7 [cytosol]

Physical Entity
Git1:p-S516-Arhgef7 [cytosol] (Rattus norvegicus)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
p-S516-ARHGEF7 activates RAC1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-18)
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